Chemiexcitation in ex vivo porcine skin model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F25%3A73632998" target="_blank" >RIV/61989592:15310/25:73632998 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.70060" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.70060</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/pcmr.70060" target="_blank" >10.1111/pcmr.70060</a>
Alternative languages
Result language
angličtina
Original language name
Chemiexcitation in ex vivo porcine skin model
Original language description
Chemiexcitation, the formation of electronically excited states via oxidative chemical reactions, has emerged as a potentially important contributor to skin photobiology beyond direct damage caused by ultraviolet (UV) radiation. This study investigates the hypothesis that UV radiation induces chemiexcitation in skin through the formation of triplet excited carbonyls, which may transfer energy to melanin and contribute to oxidative stress even after the termination of UV exposure. Using porcine skin as a model, we demonstrate that UV exposure leads to lipid peroxidation and the subsequent formation of organic radicals, including carbon-centered (alkyl) and oxygen-centered (peroxyl and alkoxyl) species, as detected by EPR spin-trapping spectroscopy. HPLC-MS analysis revealed that short-chain carbonyl compounds, such as formaldehyde and acetaldehyde, are the predominant electronically excited species in direct chemiexcitation. These triplet carbonyls can transfer their excitation energy to melanin through photon emission (radiative transfer) or direct electron exchange (non-radiative transfer), forming melanin-based secondary excited states via indirect chemiexcitation. These findings highlight a novel, light-independent mechanism of post-UV exposure oxidative damage in the skin and suggest a possible role for chemiexcitation in processes such as photoaging and photocarcinogenesis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pigment Cell and Melanoma Research
ISSN
1755-1471
e-ISSN
1755-148X
Volume of the periodical
38
Issue of the periodical within the volume
6
Country of publishing house
DK - DENMARK
Number of pages
18
Pages from-to
"e70060-1"-"e70060-18"
UT code for WoS article
001626842500007
EID of the result in the Scopus database
2-s2.0-105018655819