Evaluation of Physicochemical Properties of Polymeric Systems for Potential Applications in Cartilage Tissue Engineering
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F25%3A73634953" target="_blank" >RIV/61989592:15310/25:73634953 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1422-0067/26/5/2057" target="_blank" >https://www.mdpi.com/1422-0067/26/5/2057</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms26052057" target="_blank" >10.3390/ijms26052057</a>
Alternative languages
Result language
angličtina
Original language name
Evaluation of Physicochemical Properties of Polymeric Systems for Potential Applications in Cartilage Tissue Engineering
Original language description
This study investigates the physicochemical properties of hydrogels based on PVA and PVP crosslinked with PEGDA, focusing on their swelling capacity, surface roughness, incubation behavior, and structural modifications upon bioactive component incorporation. Swelling analysis demonstrated that the amount and molecular weight of PEGDA significantly influences the hydrogels’ sorption properties, with the highest swelling coefficient observed for samples with 2 mL PEGDA (575 g/mol) due to a looser network structure, while the lowest was recorded for 2.5 mL PEGDA (700 g/mol), indicatinga denser network. Surface roughness analysis revealed that increasing the crosslinker amount led to higher roughness both before and after incubation, with samples containing 575 g/mol PEGDA being more susceptible to structural changes in an incubation environment. FT-IR spectroscopy confirmed the presence of characteristic functional groups, providing insight into the chemical stability and hydration properties of the hydrogels. Modification with a bioactive mixture (glucosamine, chondroitin, and MSM) was confirmed by spectral analysis, indicating successful integration without compromising the hydrogel matrix. The modified hydrogels demonstrated potential applications in regenerative medicine, particularly for joint disease treatment and cartilage tissue repair.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN
1422-0067
e-ISSN
1422-0067
Volume of the periodical
26
Issue of the periodical within the volume
5
Country of publishing house
CH - SWITZERLAND
Number of pages
19
Pages from-to
"2057-1"-"2057-19"
UT code for WoS article
001442676500001
EID of the result in the Scopus database
2-s2.0-86000552567