C-geranylated flavonoids from Paulownia tomentosa Steud. fruit as potential anti-inflammatory agents

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F22%3A73617078" target="_blank" >RIV/61989592:15640/22:73617078 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14160/22:00129753 RIV/60460709:41210/22:92271

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0378874122005487?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0378874122005487?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jep.2022.115509" target="_blank" >10.1016/j.jep.2022.115509</a>

Result language

angličtina

Original language name

C-geranylated flavonoids from Paulownia tomentosa Steud. fruit as potential anti-inflammatory agents

Original language description

Ethnopharmacological relevance: Paulownia tomentosa Steud., a traditional Chinese medicinal plant, was used for many centuries in Chinese herbal medicine as a component of remedies for many illnesses, including inflammatory diseases. It is a rich source of phenolic compounds, mainly geranylated flavonoids, which are currently studied for their promising biological activities. Aim of the study: The study aimed to isolate minor geranylated flavanones and flavones from P. tomentosa fruit and evaluate their cytotoxicity and possible anti-inflammatory effects in a cell-based model of inflammation. Materials and methods: Chromatographic separation of chloroform portion of the ethanolic extract of P. tomentosa fruit led to the isolation of twenty-seven flavonoids (1-27), twenty-six of them geranylated with different modifications and one non-geranylated flavanone, and two phenolic compounds. Compounds were identified using UV, IR, HRMS, NMR, and CD spectroscopy. Ten of these compounds (7-10, 12, 21, 22, 24, 25, and 27) were determined to be new flavonoid derivatives obtained from a natural source for the first time. Selected compounds were analyzed for cytotoxicity and anti-inflammatory potential to affect the activation of nuclear factor KB/activator protein 1 (NF-KB/AP-1) after lipopolysaccharide (LPS) stimulation. Results: All the test compounds (1-21 and 23-26) reduced the activation of NF-KB/AP-1 24 h after the addition of LPS. Eight compounds (5, 14-18, 21, and 26) were more active than prednisone, a widely used antiinflammatory drug. However, this effect was not seen significantly on the level of TNF-alpha and IL-1fl, which can be explained by the plurality of possible outcomes of activation of the NF-KB pathway in cells. Conclusions: Results of the presented study confirmed that constituents from traditional Chinese medicinal plant P. tomentosa Steud. have promising anti-inflammatory activities and can serve as a potential source of inspiration for new anti-inflammatory medications.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30107 - Medicinal chemistry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Ethnopharmacology

ISSN

0378-8741

e-ISSN

1872-7573

Volume of the periodical

296

Issue of the periodical within the volume

October

Country of publishing house

IE - IRELAND

Number of pages

14

Pages from-to

nestrankovano

UT code for WoS article

000830216700002

EID of the result in the Scopus database

2-s2.0-85133831685