Macrophage-like Cells Are Responsive to Titania Nanotube Intertube Spacing-An In Vitro Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F22%3A73618777" target="_blank" >RIV/61989592:15640/22:73618777 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1422-0067/23/7/3558" target="_blank" >https://www.mdpi.com/1422-0067/23/7/3558</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms23073558" target="_blank" >10.3390/ijms23073558</a>
Alternative languages
Result language
angličtina
Original language name
Macrophage-like Cells Are Responsive to Titania Nanotube Intertube Spacing-An In Vitro Study
Original language description
With the introduction of a new interdisciplinary field, osteoimmunology, today, it is well acknowledged that biomaterial‐induced inflammation is modulated by immune cells, primarily macrophages, and can be controlled by nanotopographical cues. Recent studies have investigated the effect of surface properties in modulating the immune reaction, and literature data indicate that various surface cues can dictate both the immune response and bone tissue repair. In this context, the purpose of the present study was to investigate the effects of titanium dioxide nanotube (TNT) interspacing on the response of the macrophage‐like cell line RAW 264.7. The cells were maintained in contact with the surfaces of flat titanium (Ti) and anodic TNTs with an intertube spacing of 20 nm (TNT20) and 80 nm (TNT80), under standard or pro‐inflammatory conditions. The results revealed that nanotube interspacing can influence macrophage response in terms of cell survival and proliferation, cellular morphology and polarization, cytokine/chemokine expression, and foreign body reaction. While the nanostructured topography did not tune the macrophages’ differentiation into osteoclasts, this behavior was significantly reduced as compared to flat Ti surface. Overall, this study provides a new insight into how nanotubes’ morphological features, particularly intertube spacing, could affect macrophage behavior.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21002 - Nano-processes (applications on nano-scale); (biomaterials to be 2.9)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1661-6596
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
7
Country of publishing house
CH - SWITZERLAND
Number of pages
22
Pages from-to
"nečíslováno"
UT code for WoS article
000781029600001
EID of the result in the Scopus database
2-s2.0-85126890204