Strong in vitro anticancer activity of copper(ii) and zinc(ii) complexes containing naturally occurring lapachol: cellular effects in ovarian A2780 cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F24%3A73626127" target="_blank" >RIV/61989592:15640/24:73626127 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/24:73626127
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2024/md/d4md00543k" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2024/md/d4md00543k</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d4md00543k" target="_blank" >10.1039/d4md00543k</a>

Result language
angličtina
Original language name
Strong in vitro anticancer activity of copper(ii) and zinc(ii) complexes containing naturally occurring lapachol: cellular effects in ovarian A2780 cells
Original language description
Copper(II) and zinc(II) complexes with lapachol (HLap) of the composition [M(Lap)(2)(N-N)] and [Cu(Lap)(H2O)(terpy)]NO3 (4), where M = Cu (1-3) or Zn (for 5-7), and N-N stands for bathophenanthroline (1 and 5), 5-methyl-1,10-phenanthroline (2 and 6), 2,2 '-bipyridine (3), 2,2 ';6 ',2 ''-terpyridine (terpy, 4) and 1,10-phenanthroline (7), were synthesised and characterised. Complexes 1-5 revealed strong in vitro antiproliferative effects against A2780, A2780R, MCF-7, PC-3, A549 and HOS human cancer lines and MRC-5 normal cells, with IC50 values above 0.5 mu M, and reasonable selectivity index (SI), with SI > 3.8 for IC50(MRC-5)/IC50(A2780). Considerable time-dependent cytotoxicity in A2780 cells was observed for complexes 6 and 7, with IC50 > 50 mu M (24 h) to ca. 4 mu M (48 h). Cellular effects of complexes 1, 5 and 7 in A2780 cells were investigated by flow cytometry revealing that the most cytotoxic complexes (1 and 5) significantly perturbed the mitochondrial membrane potential and the interaction with mitochondrial metabolism followed by the triggering of the intracellular pathway of apoptosis.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10402 - Inorganic and nuclear chemistry

Project
<a href="/en/project/GA21-19060S" target="_blank" >GA21-19060S: Anticancer active coordination compounds with multimodal effect</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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