Morphology-dependent near-infrared photothermal activity of plasmonic TiN nanobars and nanospheres for anticancer, antibacterial therapy and deep in vivo photoacoustic imaging

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F25%3A73629834" target="_blank" >RIV/61989592:15640/25:73629834 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/25:10497361 RIV/61989592:15110/25:73629834 RIV/61989592:15310/25:73629834 RIV/61989100:27640/25:10257637

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S2666523925000224" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2666523925000224</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.apsadv.2025.100713" target="_blank" >10.1016/j.apsadv.2025.100713</a>

Result language

angličtina

Original language name

Morphology-dependent near-infrared photothermal activity of plasmonic TiN nanobars and nanospheres for anticancer, antibacterial therapy and deep in vivo photoacoustic imaging

Original language description

Plasmonic titanium nitride (TiN) nanoparticles are emerging nanomaterials possessing several orders of magnitude higher absorption cross section, but also exhibit higher photostability compared to conventional photosenzitizers. In the recent years, TiN has emerged as a highly effective electrocatalytic and environmentally friendly material with good biocompatibility. Its unique physicochemical properties and cost-effectiveness are essential for wide utilization in biomedicine. However, the effect of morphology of TiN on the photothermal therapy (PTT) efficiency has not been studied yet. Here, TiN nanocrystals of two precisely defined morphologies - nanobars and nanospheres - were prepared by unique pseudomorphic conversion of TiO2 nanowires and nanospheres via nitridation at 800 °C. Due to their multiple plasmonic resonances, the resulting materials show broad optical absorption spanning the entire solar spectrum and biological window including the NIR-I (750 – 1000 nm) and NIR-II (1000 – 1350 nm). Using low power illumination 318 mW/cm2 and NIR LED irradiation 940 nm, we observed a morphology-dependent PTT bioactivity, with the TiN nanobars being more efficient in cancer HeLa cells killing, while nanospheres showed higher antimicrobial activity toward Staphylococcus aureus and Escherichia coli bacteria strains. Moreover, acute and long-term in vitro biocompatibility together with in vivo monitoring of biodistribution showing enhanced permeability and retention (EPR) effect were confirmed by photoacoustic (PA) imaging in tumor bearing mice (C57BL/6J albino, EL4 lymphoma cell line). Thus, both TiN morphologies - nanobars and nanospheres are promising candidates in theranostic application via PTT therapy and PA imaging.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30108 - Toxicology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

APPLIED SURFACE SCIENCE ADVANCES

ISSN

2666-5239

e-ISSN

2666-5239

Volume of the periodical

26

Issue of the periodical within the volume

March

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

12

Pages from-to

nestránkováno

UT code for WoS article

001430143100001

EID of the result in the Scopus database

2-s2.0-85217977590