Light Irradiation of N-Doped Graphene Acid: Metal-Free Strategy Toward Antibacterial and Antiviral Coatings With Dual Modes of Action
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F25%3A73630585" target="_blank" >RIV/61989592:15640/25:73630585 - isvavai.cz</a>
Alternative codes found
RIV/61989100:27640/25:10257640
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/eom2.70009" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/eom2.70009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/eom2.70009" target="_blank" >10.1002/eom2.70009</a>
Alternative languages
Result language
angličtina
Original language name
Light Irradiation of N-Doped Graphene Acid: Metal-Free Strategy Toward Antibacterial and Antiviral Coatings With Dual Modes of Action
Original language description
The increasing emergence of antimicrobial resistance and the development of new infective viral strains represent a constantly growing threat. Metal-based nanomaterials have emerged as promising tools in the fight against bacterial and viral infections; however, the release of metal nanoparticles/ions in clinical applications may cause undesired side effects (allergies, systemic toxicity), reducing their practical use in antimicrobial treatment. Moreover, the metal-based nanoparticles possess predominantly antibacterial effects, while their antiviral efficiency remains controversial. Thus, the development of metal-free strategies enabling combined antibacterial/antiviral properties is a significant challenge. Here, we report a strategy based on light irradiation of nitrogen-doped graphene acid (NGA) possessing dual photothermal and photodynamic modes of action. The antimicrobial activity is activated through a clinically approved near-infrared (NIR) light source, and both viral and bacterial spreading can be hampered on the coating irradiation on a scale of minutes (5 to 10 min). The developed metal-free strategy reduced 90.9% and 99.99% for S. aureus and P. aeruginosa, respectively, as well as 99.97% for murine hepatitis virus. Importantly, this research represents a significant advancement in the development of safe, metal-free, and effective antimicrobial treatments. NGA coatings are safe for skin, showing no sensitization or irritation, and offer significant potential for advanced antimicrobial treatments.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
<a href="/en/project/EH22_008%2F0004587" target="_blank" >EH22_008/0004587: Technology Beyond Nanoscale</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ECOMAT
ISSN
2567-3173
e-ISSN
2567-3173
Volume of the periodical
7
Issue of the periodical within the volume
4
Country of publishing house
AU - AUSTRALIA
Number of pages
15
Pages from-to
nestránkováno
UT code for WoS article
001454149700001
EID of the result in the Scopus database
2-s2.0-105001723825