Nickel-Catalyzed Reductive Hydrolysis of Nitriles to Alcohols
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F25%3A73630826" target="_blank" >RIV/61989592:15640/25:73630826 - isvavai.cz</a>
Alternative codes found
RIV/61989100:27640/25:10256268
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/anie.202414689" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/anie.202414689</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/anie.202414689" target="_blank" >10.1002/anie.202414689</a>
Alternative languages
Result language
angličtina
Original language name
Nickel-Catalyzed Reductive Hydrolysis of Nitriles to Alcohols
Original language description
Nitriles are an abundant class of compounds that are widely used as versatile feedstocks to produce various chemicals including pharmaceuticals, and agrochemicals as well as materials. Here we report Ni-catalyzed reductive hydrolysis of nitriles to alcohols in the presence of molecular hydrogen. This conversion likely occurs in a domino reaction sequence that first involves the hydrogenation of nitrile to primary imine, then the hydrolysis of imine, and subsequent deamination to the aldehyde, which is finally hydrogenated to the desired alcohol. Crucial for this reductive hydrolysis process is the commercially available triphos-ligated Ni-complex that enables highly efficient and selective transformation of aromatic, heterocyclic, and aliphatic nitriles including fatty nitriles to prepare functionalized primary alcohols. Further, the synthetic applicability of this Ni-based protocol is presented for the selective conversion of nitrile to alcoholic group in structurally diverse and complex drug molecules as well as agrochemicals. The resulting products, alcohols are indispensable chemicals commonly used in organic synthesis and life sciences as well as material and energy technologies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21001 - Nano-materials (production and properties)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN
1433-7851
e-ISSN
1521-3773
Volume of the periodical
64
Issue of the periodical within the volume
10
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
nestránkováno
UT code for WoS article
001387345100001
EID of the result in the Scopus database
2-s2.0-85213799539