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G4Killer web application: a tool to design G-quadruplex mutations

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43110%2F20%3A43917492" target="_blank" >RIV/62156489:43110/20:43917492 - isvavai.cz</a>

  • Alternative codes found

    RIV/68081707:_____/20:00539893 RIV/00216305:26210/20:PU136592

  • Result on the web

    <a href="https://doi.org/10.1093/bioinformatics/btaa057" target="_blank" >https://doi.org/10.1093/bioinformatics/btaa057</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1093/bioinformatics/btaa057" target="_blank" >10.1093/bioinformatics/btaa057</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    G4Killer web application: a tool to design G-quadruplex mutations

  • Original language description

    Motivation: G-quadruplexes (G4) are important regulatory non-B DNA structures with therapeutic potential. A tool for rational design of mutations leading to decreased propensity for G4 formation should be useful in studying G4 functions. Although tools exist for G4 prediction, no easily accessible tool for the rational design of G4 mutations has been available. Results: We developed a web-based tool termed G4Killer that is based on the G4Hunter algorithm. This new tool is a platform-independent and user-friendly application to design mutations crippling G4 propensity in a parsimonious way (i.e., keeping the primary sequence as close as possible to the original one). The tool is integrated into our DNA analyzer server and allows for generating mutated DNA sequences having the desired lowered G4Hunter score with minimal mutation steps.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Bioinformatics

  • ISSN

    1367-4803

  • e-ISSN

  • Volume of the periodical

    36

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    2

  • Pages from-to

    3246-3247

  • UT code for WoS article

    000537447900040

  • EID of the result in the Scopus database

    2-s2.0-85084694274