G4Killer web application: a tool to design G-quadruplex mutations
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43110%2F20%3A43917492" target="_blank" >RIV/62156489:43110/20:43917492 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/20:00539893 RIV/00216305:26210/20:PU136592
Result on the web
<a href="https://doi.org/10.1093/bioinformatics/btaa057" target="_blank" >https://doi.org/10.1093/bioinformatics/btaa057</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/bioinformatics/btaa057" target="_blank" >10.1093/bioinformatics/btaa057</a>
Alternative languages
Result language
angličtina
Original language name
G4Killer web application: a tool to design G-quadruplex mutations
Original language description
Motivation: G-quadruplexes (G4) are important regulatory non-B DNA structures with therapeutic potential. A tool for rational design of mutations leading to decreased propensity for G4 formation should be useful in studying G4 functions. Although tools exist for G4 prediction, no easily accessible tool for the rational design of G4 mutations has been available. Results: We developed a web-based tool termed G4Killer that is based on the G4Hunter algorithm. This new tool is a platform-independent and user-friendly application to design mutations crippling G4 propensity in a parsimonious way (i.e., keeping the primary sequence as close as possible to the original one). The tool is integrated into our DNA analyzer server and allows for generating mutated DNA sequences having the desired lowered G4Hunter score with minimal mutation steps.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioinformatics
ISSN
1367-4803
e-ISSN
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Volume of the periodical
36
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
2
Pages from-to
3246-3247
UT code for WoS article
000537447900040
EID of the result in the Scopus database
2-s2.0-85084694274