Caspase 3 activity and carbonyl cyanide m-chlorophenyl-hydrazone-induced apoptosis in HL-60

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F00%3A21101026" target="_blank" >RIV/62156489:43210/00:21101026 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Caspase 3 activity and carbonyl cyanide m-chlorophenyl-hydrazone-induced apoptosis in HL-60

Original language description

We examined the role of caspase proteases in carbonyl cyanide m-chlorophenyl-hydrazone (mCCCP) -induced apoptosis of human promyelocytic HL-60 cells. Treatment of HL-60 cells with micromolar concentration of mCCCP resulted in cell death due to mitochondrial failure of ATP synthesis. Cell death induced by mCCCP exhibited typical apoptotic features such as chromatin condensation, apoptotic bodies formation, nucleosomal fragmentation of DNA, and distinct increase in caspase 3 activity. However, although mCCCP-induced apoptosis was accompanied by activation of caspase 3, its full inhibition by selective inhibitor, Z-DEVD-FMK, neither prevented cell death

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

EF - Botany

OECD FORD branch

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Project

<a href="/en/project/VS96082" target="_blank" >VS96082: Hormonal regulation of plant growth and development</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

18th SSCT Annual Workshop on In Vitro Toxicology

ISBN

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ISSN

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e-ISSN

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Number of pages

1

Pages from-to

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Publisher name

Scandianavian Society of Cell Toxicology

Place of publication

Sollentuna, Sweden

Event location

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Event date

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Type of event by nationality

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UT code for WoS article

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