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New SNPs in the IGF2 gene and association between this gene and backfat thickness and lean meat content in Large White pigs

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F06%3A00092877" target="_blank" >RIV/62156489:43210/06:00092877 - isvavai.cz</a>

  • Alternative codes found

    RIV/67985904:_____/06:00040915

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    New SNPs in the IGF2 gene and association between this gene and backfat thickness and lean meat content in Large White pigs

  • Original language description

    IGF2-in3-G3072A is a causative mutation for paternally expressed QTL on the p arm of porcine chromosome 2 with substantial effect on muscle growth and backfat thickness. The linkage disequilibrium between IGF2-in3-G3072A and IGF2-in7-G162C (IGF2-NciI) infour breeds and associations between these polymorphisms and growth and meat performance in pigs of the Large White breed were analyzed. A significant effect of these polymorphisms on backfat thickness and lean meat content was found. In addition, we identified two new single nucleotide polymorphisms (SNPs) in intron 7 of the gene. The existence of complete linkage disequilibrium between IGF2-in3-G3072A locus in the population under study where the locus segregated and SNPs in intron 7 of the IGF2 genedetectable with simple and reliable PCR-RFLP techniques (G162C, C179G and G186T) offer possibilities to use these SNPs for genotyping of QTN in Large White and Landrace breeds.

  • Czech name

    Nové SNP v genu IGF2 a asociace mezi tímto genem a výškou hřbetního tuku a obsahem libového masa u prasat plemene bílé ušlechtilé

  • Czech description

    IGF2-in3-G3072A je kauzální mutace pro paternálně exprimovaný QTL na p raménku prasečího chromozomu 2 s významným vlivem na vývoj svalů a výšku hřbetního tuku. U čtyř plemen prasat byla sledována vazbová nerovnováha mezi IGF2-in3-G3072A a IGF2-in7-G162C(IGF2-Nci) a dále byla provedena asociační analýza mezi těmito polymorfismy a masnou užitkovostí prasat plemene bílé ušlechtilé. Byl prokázán signifikatní vliv těchto polymorfismů na výšku hřbetního tuku a obsah libového masa. Navíc byly v intronu 7 genuIGF2 nalezeny dva nové jednonukleotidové polymorfismy (SNP). Existence kompletní vazbové nerovnováhy mezi lokusem IGF2-in3-G3072A, segregujícím ve studované populaci, a SNP v intronu 7, které jsou jednoduše detekovatelné pomocí metody PCR-RFLP, nabízí možnost využití těchto SNP pro genotypizaci QTN u plemen Bílé ušlechtilé a Landrasa.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2006

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Animal Breeding and Genetics

  • ISSN

    0931-2668

  • e-ISSN

  • Volume of the periodical

  • Issue of the periodical within the volume

    123

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    4

  • Pages from-to

    204-207

  • UT code for WoS article

  • EID of the result in the Scopus database