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Study of metallothionein aggregation in dependence on redox conditions and zinc concentration by using a chip capillary electrophoresis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F10%3A00156084" target="_blank" >RIV/62156489:43210/10:00156084 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Study of metallothionein aggregation in dependence on redox conditions and zinc concentration by using a chip capillary electrophoresis

  • Original language description

    Metallothionein (MT) is a ubiquitous cysteine-rich protein. One of the most known MT's functions is heavy metals detoxification and homeostating. Nowadays it is known, that MT is involved in regulation of gene expression, transcription, embryogenesis, immunomodulation and its antiapoptotic function was discovered recently. In cancer diseases, MT is associated with its diagnostics, course, prognosis and metastating. Enhanced MT expression leads to the formation of cytostatics resistance in tumour cells.Molecular mechanisms of these processes are still insufficiently known and understood. However it is known, that MT's function is closely related to its secondary and tertiary structure. Under physiological conditions, MT contains Zn(II) ions chelated incysteine clusters. Single MT molecules differ in zinc load and oxidation state. Recently it was found, that MT can form function aggregates in dependence on redox conditions and heavy metals concentration in the cell. These aggregates ar

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/IAA401990701" target="_blank" >IAA401990701: Study of binding of platinum cytostatics to DNA structure; Influence of metallothionein</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2010

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    25th International Symposium on MICROSCALE bIOsEPARATions MSN 2010

  • ISBN

    978-80-254-6631-5

  • ISSN

  • e-ISSN

  • Number of pages

    1

  • Pages from-to

  • Publisher name

  • Place of publication

    Praha

  • Event location

    Praha, Česká republika

  • Event date

    Jan 1, 2010

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article