Study of metallothionein aggregation in dependence on redox conditions and zinc concentration by using a chip capillary electrophoresis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F10%3A00156084" target="_blank" >RIV/62156489:43210/10:00156084 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Study of metallothionein aggregation in dependence on redox conditions and zinc concentration by using a chip capillary electrophoresis
Original language description
Metallothionein (MT) is a ubiquitous cysteine-rich protein. One of the most known MT's functions is heavy metals detoxification and homeostating. Nowadays it is known, that MT is involved in regulation of gene expression, transcription, embryogenesis, immunomodulation and its antiapoptotic function was discovered recently. In cancer diseases, MT is associated with its diagnostics, course, prognosis and metastating. Enhanced MT expression leads to the formation of cytostatics resistance in tumour cells.Molecular mechanisms of these processes are still insufficiently known and understood. However it is known, that MT's function is closely related to its secondary and tertiary structure. Under physiological conditions, MT contains Zn(II) ions chelated incysteine clusters. Single MT molecules differ in zinc load and oxidation state. Recently it was found, that MT can form function aggregates in dependence on redox conditions and heavy metals concentration in the cell. These aggregates ar
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/IAA401990701" target="_blank" >IAA401990701: Study of binding of platinum cytostatics to DNA structure; Influence of metallothionein</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
25th International Symposium on MICROSCALE bIOsEPARATions MSN 2010
ISBN
978-80-254-6631-5
ISSN
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e-ISSN
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Number of pages
1
Pages from-to
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Publisher name
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Place of publication
Praha
Event location
Praha, Česká republika
Event date
Jan 1, 2010
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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