Electrophoretic fingerprint metallothionein analysis as a potential prostate cancer biomarke
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F11%3A00173489" target="_blank" >RIV/62156489:43210/11:00173489 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/elps.201000519" target="_blank" >http://dx.doi.org/10.1002/elps.201000519</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/elps.201000519" target="_blank" >10.1002/elps.201000519</a>
Alternative languages
Result language
angličtina
Original language name
Electrophoretic fingerprint metallothionein analysis as a potential prostate cancer biomarke
Original language description
Prostate-specific antigen (PSA) is a routinely used marker of prostate cancer; however, the cut-off values for unambiguous positive/negative prostate cancer diagnoses are not defined. Therefore, despite the best effort, certain percentage of misdiagnosedcases is being recorded every year. For this reason, search formore specific diagnosticmarkers is of great interest. In this study, systematic comparison of PSA and metallothionein (MT) levels in blood serum of 46 prostate cancer-diagnosed patients is presented. It is clearly demonstrated that PSA levels vary significantly and despite normal total PSA values in the range of 0 -- 4 ng/mL were obtained in over 36.9% of cases, positive prostate cancer was diagnosed by biopsy. In contrary, MT levels were considerably elevated in all tested samples and no significant variations were observed. These results are indicating the potential of MT as an additional prostate cancer marker reducing, in combination with PSA, the probability of false p
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CG - Electrochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/KAN208130801" target="_blank" >KAN208130801: New design and exploiting nanobiosensors and nanosensors to target medicine (NANOSEMED)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Electrophoresis
ISSN
0173-0835
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
15
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
1952-1961
UT code for WoS article
294179800005
EID of the result in the Scopus database
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