Analysis of metallothionein isoforms by capillary electrophoresis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F11%3A00173954" target="_blank" >RIV/62156489:43210/11:00173954 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Analysis of metallothionein isoforms by capillary electrophoresis
Original language description
Prostate cancer (CaP) is the second most frequently diagnosed cancer in developed countries and the third most common cancer causing death in men. Number of compounds is tested as potential CaP markers to improve the reliability of commonly used tests. Metallothionein (MT), due to its properties including high cysteine content, high heavy metal affinity and thermostability, is extensively studied as a potential cancer marker. Two major isoforms (MT-1, MT-2) have been identified in mammals and diagnosticpotential of their ratio is investigated. Capillary electrophoresis is a separation effective tool enabling separation and identification of MT isoforms in mixtures. However the complexity of real samples requires sample pre-treatment to obtain valuableresults and minimize the interferences of other compounds. Thermal denaturation of the sample is one of the simplest and often used methods for elimination of interfering components taking advantage of the MT's thermostability. The effec
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
XI. pracovní setkání fyzikálních chemiků a elektrochemiků
ISBN
978-80-7375-514-0
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
228-232
Publisher name
Mendelova univerzita v Brně
Place of publication
Brno
Event location
MENDELU
Event date
Jan 1, 2011
Type of event by nationality
CST - Celostátní akce
UT code for WoS article
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