The anticancer drug ellipticine induces cytochrome b5 and cytochromes p450 1a1, 1a2 and 3a in rat liver, kidney and lung

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F12%3A00190285" target="_blank" >RIV/62156489:43210/12:00190285 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The anticancer drug ellipticine induces cytochrome b5 and cytochromes p450 1a1, 1a2 and 3a in rat liver, kidney and lung
Original language description
The antineoplastic alkaloid ellipticine is a prodrug, whose pharmacological efficiency is dependent on its cytochrome P450 (CYP)- and/or peroxidase-mediated activation in target tissues. This compound was found to induce expression of cytochrome b5, CYP1A1, 1A2 and 3A proteins determined electrochemically (Western blotting) and their enzymatic activities in livers, lungs and kidneys of rats treated (i.p.) with ellipticine. In addition, induction of these proteins resulted in an increase in ellipticine oxidation to 7-hydroxy-, 9-hydroxy-, 13-hydroxy- and 12-hydroxyellipticine, the metabolites that are both detoxication products (7-hydroxy-, 9-hydroxyellipticine) and metabolites responsible for generation elliptiicne-derived DNA adducts (12-hydroxy- and13-hydroxyellipticine). The results demonstrate that by inducing CYP1A1/2, 3A and cytochrome b5, ellipticine increases its own metabolism leading both to an activation of this drug to reactive species forming DNA adducts and to detoxicati
Czech name
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Czech description
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Project
<a href="/en/project/GAP301%2F10%2F0356" target="_blank" >GAP301/10/0356: Study of contribution of different DNA-damaging mechanisms to toxicity of cytostatics to human chemosensitive and chemoresistant neuroblastomas</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
XII. Pracovní setkání fyzikálních chemiků a elektrochemiků
ISBN
978-80-7375-618-5
ISSN
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e-ISSN
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Number of pages
3
Pages from-to
357-359
Publisher name
Mendelova univerzita v Brně
Place of publication
Mendelova univerzita v Brně
Event location
Brno, Česká republika
Event date
Jan 1, 2012
Type of event by nationality
CST - Celostátní akce
UT code for WoS article
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