Apoferritin as a targeted drug delivery system

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F13%3A43908859" target="_blank" >RIV/62156489:43210/13:43908859 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/13:PU125823 RIV/00216305:26620/13:PU126757
Result on the web
<a href="https://mnet.mendelu.cz/mendelnet2013/mnet_2013_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2013/mnet_2013_full.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Apoferritin as a targeted drug delivery system
Original language description
Conventional cancer treatment often effects normal cells and has many side effects. These can be addressed by the use of nanomedicine, especially its platform nanotransporters, in which cytostatic drug can be encapsulated. These nanotransporters can be dispersed in tumors through relatively large pores in tumor blood vessels but not in normal blood vessels. The nanotransporters can be coupled with antibodies, thus allowing targeted delivery of drugs. For this coupling we chose the method using linker, small peptide that interacts with Fc region of IgG antibodies, presenting the antigen binding site facing out. The aim of this experiment was to create, characterize and test a nanotransporter based on apoferritin nanocage with encapsulated doxorubicin, modified with specific antibody. As a linker, heptapeptide HWRGWVC was used. Cysteine has known affinity towards gold, two methods of apoferritin surface modification were proposed and better results were obtained with apoferritin modified
Czech name
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Czech description
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Project
<a href="/en/project/GAP301%2F10%2F0356" target="_blank" >GAP301/10/0356: Study of contribution of different DNA-damaging mechanisms to toxicity of cytostatics to human chemosensitive and chemoresistant neuroblastomas</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
MendelNet 2013: Proceedings of International PhD Students Conference
ISBN
978-80-7375-908-7
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
908-912
Publisher name
Mendelova univerzita v Brně
Place of publication
Brno
Event location
Brno
Event date
Nov 20, 2013
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000366464800160

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