Characterization of Multi-Walled Carbon Nanotubes Double-Functionalization with Cytostatic Drug Etoposide and Phosphorothioate Oligodeoxynucleotides
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F15%3A43907682" target="_blank" >RIV/62156489:43210/15:43907682 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/15:10306887 RIV/00216305:26620/15:PU118482 RIV/00064203:_____/15:10306887
Result on the web
<a href="http://www.electrochemsci.org/papers/vol10/100907707.pdf" target="_blank" >http://www.electrochemsci.org/papers/vol10/100907707.pdf</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Characterization of Multi-Walled Carbon Nanotubes Double-Functionalization with Cytostatic Drug Etoposide and Phosphorothioate Oligodeoxynucleotides
Original language description
Carbon nanomaterials possess unique structural and physicochemical properties, and thus they are broadly utilized as carriers for a variety of therapeutic agents in nanomedicinal applications. Herein we present an electrochemical characterization of binding capability of acidic oxidized multi-walled carbon nanotubes (oMWCNTs) modified with poly(ethylene glycol) towards common cytostatic drug etoposide (or VP-16). The comparison of willingness of oMWCNTs and MWCNTs-PEG to form complexes with etoposide revealed significantly higher capacity in PEGylated variant of carbon nanotubes (the 15 mM etoposide loading capacity was approximately 46.4% in 2 mg of MWCNT-PEG or 28.1% in equal amount of oMWCNT). To obtain a multifunctional nanotransporter we employedthe phosphorothioate oligodeoxynucleotide (PODN), which could further extend the possible biological effects of MWCNT-PEG-Etoposide complex. By using square wave voltammetry, the binding capacity of 2 mg of MWCNT-PEG-Etoposide (15 mM) tow
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CG - Electrochemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Electrochemical Science
ISSN
1452-3981
e-ISSN
—
Volume of the periodical
10
Issue of the periodical within the volume
9
Country of publishing house
CS - SERBIA AND MONTENEGRO
Number of pages
13
Pages from-to
7707-7719
UT code for WoS article
000365101700069
EID of the result in the Scopus database
—