Melatonin Regulates Oxidative Stress Initiated by Freund's Complete Adjuvant
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F15%3A43907744" target="_blank" >RIV/62156489:43210/15:43907744 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/15:43875482
Result on the web
<a href="http://actamedica.lfhk.cuni.cz/media/pdf/am_2015058010021.pdf" target="_blank" >http://actamedica.lfhk.cuni.cz/media/pdf/am_2015058010021.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14712/18059694.2015.87" target="_blank" >10.14712/18059694.2015.87</a>
Alternative languages
Result language
angličtina
Original language name
Melatonin Regulates Oxidative Stress Initiated by Freund's Complete Adjuvant
Original language description
Melatonin is a hormone with strong antioxidant properties. In this experiment, Freund's complete adjuvant was used as a stressogenic substance given to laboratory outbred mice, whereas melatonin was investigated as a protectant against the stressogenic effect. Levels of low molecular weight antioxidants, thiobarbituric acid reactive substances, and tumor necrosis factor α and activity of glutathione reductase were determined in blood from the animals. Surprisingly, melatonin was not involved in direct regulation of antioxidants, thiobarbituric acid reactive substances and tumor necrosis factor α. On the other hand, melatonin regulated glutathione reductase activity. We can conclude on regulation of metabolism caused by melatonin in the model. The effect was more important than the expected regulation of immunity and basal oxidative homeostasis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Medica Hradec Kralove
ISSN
1211-4286
e-ISSN
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Volume of the periodical
58
Issue of the periodical within the volume
1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
4
Pages from-to
21-24
UT code for WoS article
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EID of the result in the Scopus database
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