Modeling of the Antiviral Peptide for Specific Inhibition of Influenza Virus Entry

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F15%3A43907813" target="_blank" >RIV/62156489:43210/15:43907813 - isvavai.cz</a>

Result on the web

<a href="http://www.jscimedcentral.com/DrugDesign/drugdesign-2-1010.pdf" target="_blank" >http://www.jscimedcentral.com/DrugDesign/drugdesign-2-1010.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Modeling of the Antiviral Peptide for Specific Inhibition of Influenza Virus Entry

Original language description

Influenza is a highly pathogenic virus well known by a higher mutation rate, resulted from antigenic drift and shift of its surface proteins. The hemagglutinin- influenza major virus surface protein is responsible for viral entry through targeting sialicacid present on the lipid membrane of the host cell. Nowadays, peptides become the perspective therapeutic agents for various infection diseases including influenza. Utilization of peptides could provide high specifity, attained by a number of possiblemodifications, which can be simply proposed by using in silicomodeling. Molecular modeling of peptides with high affinity towards sialic acid binding site of influenza hemagglutinin may be thus helpful for inhibition of viral entry. Hence, we employed Yasara program for molecular modeling to estimate a binding energy of selected peptides to specific hemagglutinin binding site in the amino acids range of 116 - 261. We designed a mimicking peptide with sequence WLVFFVIFYIFR showing binding

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

<a href="/en/project/GAP102%2F11%2F1068" target="_blank" >GAP102/11/1068: Nano-Electro-Bio-Tools for Biochemical and Molecularly-Biological Studies of Eukaryotic Cells (NanoBioTECell)</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Drug Design and Research

ISSN

2379-089X

e-ISSN

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Volume of the periodical

2

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

2

Pages from-to

"nestrankovano"

UT code for WoS article

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EID of the result in the Scopus database

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