Structural attributes and binding role of HIV-1 exterior envelope g p120

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F15%3A43907835" target="_blank" >RIV/62156489:43210/15:43907835 - isvavai.cz</a>
Result on the web
<a href="http://web2.mendelu.cz/af_239_nanotech/J_Met_Nano/0115/pdf/JMN1-2015-7.pdf" target="_blank" >http://web2.mendelu.cz/af_239_nanotech/J_Met_Nano/0115/pdf/JMN1-2015-7.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Structural attributes and binding role of HIV-1 exterior envelope g p120
Original language description
Glycoprotein 120 (gp120) plays pivotal role in HIV-1 entry into the host cells, resulting from interaction of gp120 highly conservative CD4 binding site and CD4 receptor on the surface of CD4+T cells. Therefore, gp120 became a major target in developmentof vaccines for HIV-1 management, based on competitive neutralization of gp120, disabling entry into the host cell. Present study describes the structure of HIV-1 virion and its pivotal protein - gp120, together with mechanism of viral entry through interaction between gp120 CD4 binding site and CD4 receptor. Finally, basic antibodies, suitable for HIV-1 vaccination are commented, with focus on RV144 or the Thai trial (ongoing clinical trial, phase III). .
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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