Biological activity of Schiff base peptide complexes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F16%3A00092152" target="_blank" >RIV/62156489:43210/16:00092152 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/16:PU122879
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Biological activity of Schiff base peptide complexes
Original language description
Eu(III) and Tb(III) Schiff base complexes are applicable in various fields such as sensing, assays, screening protocols in vitro, and imaging studies in vitro or in vivo. Fluorescent europium and terbium complexes and their interaction with cell penetrating peptide (KKKRKC) can represent an excellent key for understanding pathway of peptide transportation though cell membrane and the application of Schiff base complexes as potential antibacterial drugs. The Schiff base-metal complexes and its conjugates with peptide were tested for their antibacterial activity to assess their inhibiting potential against Pseudomonas aeruginosa and Salmonella typhimurium. Schiff base-metal complexes conjugated with peptide show minor toxicity in normal human PNT1A cells and high antibacterial activity against Pseudomonas aeruginosa and Salmonella typhimurium, where IC50 down to 125.9 muM and/or 36.1 muM were found for Pseudomonas aeruginosa and Salmonella typhimurium, respectively. Our results strongly suggest that Schiff base-metal complexes conjugated with peptide have great potential to be used as effective antibacterial drug.
Czech name
—
Czech description
—

Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)