Metal Containing Cytostatics and Their Interaction with Cellular Thiol Compounds Causing Chemoresistance

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F16%3A43909565" target="_blank" >RIV/62156489:43210/16:43909565 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/16:10313537 RIV/00216208:11130/16:10313537 RIV/00216305:26620/16:PU120129 RIV/00064203:_____/16:10313537

Result on the web

<a href="http://dx.doi.org/10.2174/1871520616666151120122611" target="_blank" >http://dx.doi.org/10.2174/1871520616666151120122611</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1871520616666151120122611" target="_blank" >10.2174/1871520616666151120122611</a>

Result language

angličtina

Original language name

Metal Containing Cytostatics and Their Interaction with Cellular Thiol Compounds Causing Chemoresistance

Original language description

The history of metal based cytostatics began in the 1970s by discovering the effects of cisplatin. Since then several generations of platinum based cytostatics have started to be the key weapon against tumor development and metastasis occurrence. Nevertheless, some attention has been also paid to non-platinum metals, such as ruthenium, titanium, gallium, iron, cobalt, gold, and palladium. Ruthenium, titanium, and gallium complexes have been also tested in clinical studies. This boom in metal based cytostatics can be explained by great effort paid to the elucidation of mechanisms of tumor resistance to these drugs. The known mechanisms of drug resistance are: (i) down regulation, over-expression, or modification of molecules of interest; (ii) increased drug efflux; (iii) induction of anti-apoptotic mechanisms or inactivation of pro-apoptotic mechanisms; (iv) changes in enzymes with an ability to activate or detoxify a drug; (v) low access of the drug to a tumor; and/or (vi) alteration in drug metabolism or excretion [1]. Often discussed but not largely reviewed and summarized is the intracellular inactivation of platinum drugs by coordination to thiol containing biomolecules glutathione (GSH) and metallothioneins (MTs). Overexpression of MT and/or GSH may cause resistance to anticancer drugs. Thus, greater attention should be paid to these interactions in case to overcome the resistance of tumor to cytostatics.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anti-Cancer Agents in Medicinal Chemistry

ISSN

1871-5206

e-ISSN

—

Volume of the periodical

16

Issue of the periodical within the volume

6

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

13

Pages from-to

686-698

UT code for WoS article

000375138000003

EID of the result in the Scopus database

2-s2.0-84966430731