Peptide Modified Carbon Nanotubes for Drug Delivery

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F16%3A43910239" target="_blank" >RIV/62156489:43210/16:43910239 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/16:PU124202
Result on the web
<a href="https://mnet.mendelu.cz/mendelnet2016/mnet_2016_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2016/mnet_2016_full.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Peptide Modified Carbon Nanotubes for Drug Delivery
Original language description
Multi-walled-carbon nanotubes (MWCNTs) are widely explored as carriers for drug delivery, due to their facile transport through cellular membranes, and are reportedly found to be effective against cancer. In the present study, we have designed a MWCNTs nanocarrier for doxorubicin delivery to prostate cancer tissue. The cell penetrating peptide (SMSIALR) modified MWCNTs provide better penetration of nanocarrier into cancer cells. Using fluorescence measurement, the doxorubicin (DOXO) binding efficiency was estimated to 100%. MALDI analysis confirms the presence of doxorubicin and peptide on the MWCNTs structure. The stability behavior of the colloid suspension indicates the positive charge of carbon nanocarrier and due to this fact, the cancer cells membranes carry negative charge, the MWCNTs is established as suitable drug delivery system for doxorubicin.
Czech name
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Czech description
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Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
MendelNet 2016: Proceedings of International PhD Students Conference
ISBN
978-80-7509-443-8
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
999-1004
Publisher name
Mendelova univerzita v Brně
Place of publication
Brno
Event location
Brno
Event date
Nov 9, 2016
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
000392968500179

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