Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F17%3A43911834" target="_blank" >RIV/62156489:43210/17:43911834 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/17:00094919 RIV/00216305:26620/17:PU124805

Result on the web

<a href="https://doi.org/10.1002/jbt.21891" target="_blank" >https://doi.org/10.1002/jbt.21891</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jbt.21891" target="_blank" >10.1002/jbt.21891</a>

Result language

angličtina

Original language name

Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease

Original language description

Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT), metals (zinc and copper), and selected antioxidants (bilirubin, cysteine, and glutathione)were determined in 70 type 2 diabetes mellitus (T2DM) subjects and 80 healthy subjects of Caucasian origin. Single nucleotide polymorphism (rs28366003) in MT gene was detected. Antiradical capacity, conjugated bilirubin, and copper were significantly increased in diabetics, whereasMTand glutathione were decreased. GenotypeAAof rs28366003 was associated with higher zinc levels in the diabetic group. The studied parameterswere not influenced by renal function. This is the first study comprehensively investigating differences in MT and metals relevant to oxidative stress in T2DM. Ascertained differences indicate increased oxidative stress in T2DM accompanied by abnormalities in non-enzymatic antioxidant defense systems.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Biochemical and Molecular Toxicology

ISSN

1095-6670

e-ISSN

—

Volume of the periodical

31

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

&quot;nestrankovano&quot;

UT code for WoS article

000403147800009

EID of the result in the Scopus database

2-s2.0-85008474273