Spectral analysis of human norepinephrine transporter homing peptides

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F17%3A43912624" target="_blank" >RIV/62156489:43210/17:43912624 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/17:PU128354
Result on the web
<a href="https://mnet.mendelu.cz/mendelnet2017/mnet_2017_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2017/mnet_2017_full.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Spectral analysis of human norepinephrine transporter homing peptides
Original language description
UV spectrometry is very simple and cheap method for quantitative and qualitative analysis of compounds. Furthermore, it provides intricate information about the bonded π-electron transitions and also non-bonded n-electron transitions. The aim of this work was to identify electron transition bands in two homing peptides of the human norepinephrine transporter (hNET); namely: GASNGINAYL (978 Da) and SLWERLAYGI (1206 Da). Electron transition bands directly indicate structural conformations, particularly the ones associated with double bonds, i.e. conjugated π-bonds of aromatic and peptide bonds. The results show unusual spikes in absorbance in the far UV at low temperature for GASNGINAYL and even more at other temperatures for SLWERLAYGI peptide. The latter supports the hypothesis of a stacking between tyrosine and tryptophan resulting in helix structure. Infrared spectrometry also showed abundant helix structure in SLWERLAYGI but less abundant in GASNGINAYL peptide. Based on π-stacking, an UV spectrometry method can be developed to monitor the helicity of some peptides, such as SLWERLAYGI.
Czech name
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Czech description
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Project
<a href="/en/project/GA17-12816S" target="_blank" >GA17-12816S: Construction of modified apoferritin nanocarriers bearing anticancer drugs and study of mechanisms enhancing their efficiency in anticancer therapy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
MendelNet 2017: Proceedings of International PhD Students Conference
ISBN
978-80-7509-529-9
ISSN
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e-ISSN
neuvedeno
Number of pages
6
Pages from-to
867-872
Publisher name
Mendelova univerzita v Brně
Place of publication
Brno
Event location
Brno
Event date
Nov 8, 2017
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000440194500155

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