Immunohistochemical analysis of heat shock proteins in triple negative breast cancer: HSP60 expression is a marker of poor prognosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F18%3A43914525" target="_blank" >RIV/62156489:43210/18:43914525 - isvavai.cz</a>

Result on the web

<a href="http://www.irog.net/archives" target="_blank" >http://www.irog.net/archives</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.12892/ejgo4347.2018" target="_blank" >10.12892/ejgo4347.2018</a>

Result language

angličtina

Original language name

Immunohistochemical analysis of heat shock proteins in triple negative breast cancer: HSP60 expression is a marker of poor prognosis

Original language description

Triple negative breast cancer (TNBC) is an aggressive and rapidly growing subtype of breast cancer characterized by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) expression, rendering it resistant to targeted therapies. In the absence of molecular targets, the pathogenesis of TNBC is not well understood and many studies are focused towards identifying the pathways and molecular signatures associated with the initiation and progression of TNBC. Heat shock proteins emerged as key players in the tumorigenic pathways of several types of cancer including TNBC. In the present study, paraffin-embedded tumor tissues of 66 Jordanian TNBC patients were analyzed, retrospectively. by immunohistochemistry to investigate the expression of HSP90, HSP70, HSP60, and HSP27 in Jordanian TNBC patients. The expression of the aforementioned markers was also examined using disease-free survival (DFS) along with a variety of clinical and pathological characteristics such as age, stage/grade of tumor, and nodal involvement. Positive expression of HSP90, HSP60, HSP27, and HSP70 was shown in 89%. 79%, 76%, and 40% of the cases analyzed, respectively. HSP60 positive expression was found to be significantly correlated with advanced stage (pT3/pT4) of the tumor (p 0.05), nodal involvement (p = 0.03), and older age of patients (p = 0.03). Among the clinical and pathological variables analyzed in the present study, it was found that advanced stage (pT3/pT4) of the tumor and older age of the patients were significantly associated with worse DFS (p = 0.001 and 0.02, respectively). Additionally, positive expression of HSP60 showed to be correlated with worse DFS (p = 0.05). This study highlights the importance of HSP60 as a marker of poor prognosis in TNBC patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Gynaecological Oncology

ISSN

0392-2936

e-ISSN

—

Volume of the periodical

39

Issue of the periodical within the volume

6

Country of publishing house

CA - CANADA

Number of pages

9

Pages from-to

926-934

UT code for WoS article

000452166200014

EID of the result in the Scopus database

2-s2.0-85058863737