Nanoparticle-drug conjugates treating bacterial infections
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F19%3A43915943" target="_blank" >RIV/62156489:43210/19:43915943 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43410/19:43915943 RIV/00216305:26620/19:PU133474
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0168365919303232/pdfft?md5=2791a9f78efea6b8cc6a4614f854ded2&pid=1-s2.0-S0168365919303232-main.pdf" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0168365919303232/pdfft?md5=2791a9f78efea6b8cc6a4614f854ded2&pid=1-s2.0-S0168365919303232-main.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jconrel.2019.06.013" target="_blank" >10.1016/j.jconrel.2019.06.013</a>
Alternative languages
Result language
angličtina
Original language name
Nanoparticle-drug conjugates treating bacterial infections
Original language description
The ever increasing scenario of bacterial resistance against commonly available antibiotics is becoming a global threat of major concern, which necessitates the development of new strategies to overcome this hurdle. Conjugation of nanoparticles (NPs) with antimicrobial moieties, such as antibiotics, peptides or different biomolecules, has been one of the successful techniques in targeting antibiotic resistance. This review mainly focusses on the possible nanoparticle-drug conjugates with their activity against pathogenic bacterial infections. Nanoparticles play an array of roles, e.g. as a carrier, synergistically acting agent and as theranostic agent, henceforth facilitates the efficacy of therapy. Moreover, this review elaborates the studies with reported nanoparticles-drug conjugates that include their possible synthesis methodologies and applications. In most of the cases, the nanoparticles were found to increase the permeability of bacterial cell membrane, which enables higher uptake of antibiotics inside the bacterial cells which in return showed better effects. Even the conjugates were found to efficiently kill the antibiotic-resistant strains. Since several limitations are exerted by the biological systems, there is an urge for the advancement of nanoparticle-drug conjugates for better proficiency.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Controlled Release
ISSN
0168-3659
e-ISSN
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Volume of the periodical
307
Issue of the periodical within the volume
August
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
20
Pages from-to
166-185
UT code for WoS article
000484348600013
EID of the result in the Scopus database
2-s2.0-85067893015