Electrochemical Determination of Vitamin D3 in Pharmaceutical Products by Using Boron Doped Diamond Electrode
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43916733" target="_blank" >RIV/62156489:43210/20:43916733 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/20:PU134897
Result on the web
<a href="https://doi.org/10.1002/elan.201900532" target="_blank" >https://doi.org/10.1002/elan.201900532</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/elan.201900532" target="_blank" >10.1002/elan.201900532</a>
Alternative languages
Result language
angličtina
Original language name
Electrochemical Determination of Vitamin D3 in Pharmaceutical Products by Using Boron Doped Diamond Electrode
Original language description
A sensitive square-wave voltammetry method was developed to determine cholecalciferol (vitamin D3) in pharmaceutical products at boron-doped diamond electrode as a working electrode. Vitamin D3 provided a well-defined voltammetric peak at around +1.00 V (vs. Ag/AgCl, 3.5 mol dmMINUS SIGN 3) in 0.02 mol dmMINUS SIGN 3 Britton-Robinson buffer pH 5.0 prepared in 50 % ethanol. The influence of various factors such as type and pH of the supporting electrolyte, scan rate and square-wave parameters were studied and optimized. Under optimum conditions, the oxidation peak current increased linearly with the concentration of vitamin D3 over the range of 2 to 200 μmol dmMINUS SIGN 3. The calculated limit of detection and limit of quantitation were 0.17 μmol dmMINUS SIGN 3 and 0.51 μmol dmMINUS SIGN 3, respectively. The boron-doped diamond electrode exhibited specific recognition capability for cholecalciferol amongst possible interferences, and the determination of vitamin D3 was possible in samples such as commercial pharmaceutical products without complicated sample pretreatments.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Electroanalysis
ISSN
1040-0397
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
4
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
741-748
UT code for WoS article
000495749900001
EID of the result in the Scopus database
2-s2.0-85075018242