An RNA-dependent RNA polymerase inhibitor for tick-borne encephalitis virus
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43917722" target="_blank" >RIV/62156489:43210/20:43917722 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/20:00537396 RIV/00027162:_____/20:N0000106
Result on the web
<a href="https://doi.org/10.1016/j.virol.2020.03.006" target="_blank" >https://doi.org/10.1016/j.virol.2020.03.006</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.virol.2020.03.006" target="_blank" >10.1016/j.virol.2020.03.006</a>
Alternative languages
Result language
angličtina
Original language name
An RNA-dependent RNA polymerase inhibitor for tick-borne encephalitis virus
Original language description
Tick-borne encephalitis virus (TBEV) is a medically important representative of the Flaviviridae family. The TBEV genome encodes a single polyprotein, which is co/post-translationally cleaved into three structural and seven non-structural proteins. Of the non-structural proteins, NS5, contains an RNA-dependent RNA polymerase (RdRp) domain that is highly conserved and is responsible for the genome replication. Screening for potential antivirals was done using a hybrid receptor and ligand-based pharmacophore search likely targeting the RdRp domain. For the identification of pharmacophores, a mixture of small probe molecules and nucleotide triphosphates were used. The ligand/receptor interaction screenings of structures from the ZINC database resulted in five compounds. Zinc 3677 and 7151 exhibited lower cytotoxicity and were tested for their antiviral effect against TBEV in vitro. Zinc 3677 inhibited TBEV at micromolar concentrations. The results indicate that Zinc 3677 represents a good target for structure-activity optimizations leading potentially to a discovery of effective TBEV antivirals.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10607 - Virology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Virology
ISSN
0042-6822
e-ISSN
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Volume of the periodical
546
Issue of the periodical within the volume
July
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
13-19
UT code for WoS article
000536213500002
EID of the result in the Scopus database
2-s2.0-85082941140