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Apoptosis of Eosinophil Granulocytes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43918775" target="_blank" >RIV/62156489:43210/20:43918775 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.3390/biology9120457" target="_blank" >https://doi.org/10.3390/biology9120457</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/biology9120457" target="_blank" >10.3390/biology9120457</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Apoptosis of Eosinophil Granulocytes

  • Original language description

    In the past 10 years, the number of people in the Czech Republic with allergies has doubled to over three million. Allergic pollen catarrh, constitutional dermatitis and asthma are the allergic disorders most often diagnosed. Genuine food allergies today affect 6-8% of nursing infants, 3-5% of small children, and 2-4% of adults. These disorders are connected with eosinophil granulocytes and their apoptosis. Eosinophil granulocytes are postmitotic leukocytes containing a number of histotoxic substances that contribute to the initiation and continuation of allergic inflammatory reactions. Eosinophilia results from the disruption of the standard half-life of eosinophils by the expression of mechanisms that block the apoptosis of eosinophils, leading to the development of chronic inflammation. Glucocorticoids are used as a strong acting anti-inflammatory medicine in the treatment of hypereosinophilia. The removal of eosinophils by the mechanism of apoptosis is the effect of this process. This work sums up the contemporary knowledge concerning the apoptosis of eosinophils, its role in the aforementioned disorders, and the indications for the use of glucocorticoids in their related therapies.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10601 - Cell biology

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biology

  • ISSN

    2079-7737

  • e-ISSN

  • Volume of the periodical

    9

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    15

  • Pages from-to

    457

  • UT code for WoS article

    000601877800001

  • EID of the result in the Scopus database

    2-s2.0-85099298362