Viral Pandemics of the Last Four Decades: Pathophysiology, Health Impacts and Perspectives

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43918797" target="_blank" >RIV/62156489:43210/20:43918797 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.3390/ijerph17249411" target="_blank" >https://doi.org/10.3390/ijerph17249411</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijerph17249411" target="_blank" >10.3390/ijerph17249411</a>

Result language

angličtina

Original language name

Viral Pandemics of the Last Four Decades: Pathophysiology, Health Impacts and Perspectives

Original language description

The twenty-first century has witnessed some of the deadliest viral pandemics with far-reaching consequences. These include the Human Immunodeficiency Virus (HIV) (1981), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) (2002), Influenza A virus subtype H1N1 (A/H1N1) (2009), Middle East Respiratory Syndrome Coronavirus (MERS-CoV) (2012) and Ebola virus (2013) and the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) (2019-present). Ageand gender-based characterizations suggest that SARS-CoV-2 resembles SARS-CoV and MERS-CoV with regard tohigher fatality rates in males, and in the older population with comorbidities. The invasion-mechanism of SARS-CoV-2 and SARS-CoV, involves binding of its spike protein with angiotensin-converting enzyme 2 (ACE2) receptors; MERS-CoV utilizes dipeptidyl peptidase 4 (DPP4), whereas H1N1 influenza is equipped with hemagglutinin protein. The viral infections-mediated immunomodulation, and progressive inflammatory state may affect the functions of several other organs. Although no effective commercial vaccine is available for any of the viruses, those against SARS-CoV-2 are being developed at an unprecedented speed. Until now, only Pfizer/BioNTech&apos;s vaccine has received temporary authorization from the UK Medicines and Healthcare products Regulatory Agency. Given the frequent emergence of viral pandemics in the 21st century, proper understanding of their characteristics and modes of action are essential to address the immediate and long-term health consequences.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30302 - Epidemiology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Environmental Research and Public Health

ISSN

1661-7827

e-ISSN

—

Volume of the periodical

17

Issue of the periodical within the volume

24

Country of publishing house

CH - SWITZERLAND

Number of pages

39

Pages from-to

9411

UT code for WoS article

000602822200001

EID of the result in the Scopus database

2-s2.0-85097909193