Effects of diclofenac and ibuprofen on fish embryos

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43919558" target="_blank" >RIV/62156489:43210/20:43919558 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16270/20:43879752
Result on the web
<a href="https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Effects of diclofenac and ibuprofen on fish embryos
Original language description
Contamination of aquatic environment results in negative effects on both human and aquatic biota. Diclofenac and ibuprofen are commonly used pharmacologically active substances, which are found in aquatic environment. Occurrence of their residues in the aquatic environment is caused by constantly increasing consumption, discharge in wastewater and its imperfect purification in wastewater treatment plants. The aim of this study was to assess the impact of diclofenac and ibuprofen residues on embryonic stages of zebrafish (Danio rerio). The study was performed according to the acute toxicity test on zebrafish embryos guideline no. 236. Six different concentrations of diclofenac and ibuprofen were tested. Lethal and various sublethal effects of diclofenac and ibuprofen were observed at concentrations ranging from 2 000 μg/l to 20 000 μg/l. The most frequently negative effect was observed on the cardiovascular system, where heart edema of embryos occurred. Moreover, the results suggest negative effects on hatching. For example in the end of the experiment at the highest tested concentration of ibuprofen was hatched only 37.14% embryos. Our study showed that the non-steroidal anti-inflammatory drugs (NSAIDs) diclofenac and ibuprofen have a negative effect on the development of fish embryos.
Czech name
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Czech description
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Project
<a href="/en/project/EF16_019%2F0000869" target="_blank" >EF16_019/0000869: Sustainable production of healthy fish in various aquaculture systems - PROFISH</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
MendelNet 2020: Proceedings of International PhD Students Conference
ISBN
978-80-7509-765-1
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
195-198
Publisher name
Mendelova univerzita v Brně
Place of publication
Brno
Event location
Brno
Event date
Nov 11, 2020
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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