Ferroptosis: A New Road towards Cancer Management
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F22%3A43921282" target="_blank" >RIV/62156489:43210/22:43921282 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.3390/molecules27072129" target="_blank" >https://doi.org/10.3390/molecules27072129</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules27072129" target="_blank" >10.3390/molecules27072129</a>
Alternative languages
Result language
angličtina
Original language name
Ferroptosis: A New Road towards Cancer Management
Original language description
Ferroptosis is a recently described programmed cell death mechanism that is characterized by the buildup of iron (Fe)-dependent lipid peroxides in cells and is morphologically, biochemically, and genetically distinct from other forms of cell death, having emerged to play an important role in cancer biology. Ferroptosis has significant importance during cancer treatment because of the combination of factors, including suppression of the glutathione peroxidase 4 (Gpx4), cysteine deficiency, and arachidonoyl (AA) peroxidation, which cause cells to undergo ferroptosis. However, the physiological significance of ferroptosis throughout development is still not fully understood. This current review is focused on the factors and molecular mechanisms with the diagrammatic illustrations of ferroptosis that have a role in the initiation and sensitivity of ferroptosis in various malignancies. This knowledge will open a new road for research in oncology and cancer management.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecules
ISSN
1420-3049
e-ISSN
1420-3049
Volume of the periodical
27
Issue of the periodical within the volume
7
Country of publishing house
CH - SWITZERLAND
Number of pages
22
Pages from-to
2129
UT code for WoS article
000781845000001
EID of the result in the Scopus database
2-s2.0-85127486662