Genetically modified rodent models and celiac, non-celiac gluten sensitivity: a minireview

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F22%3A43921786" target="_blank" >RIV/62156489:43210/22:43921786 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17110/22:A2402FQJ

Result on the web

<a href="https://doi.org/10.21101/cejph.a6810" target="_blank" >https://doi.org/10.21101/cejph.a6810</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21101/cejph.a6810" target="_blank" >10.21101/cejph.a6810</a>

Result language

angličtina

Original language name

Genetically modified rodent models and celiac, non-celiac gluten sensitivity: a minireview

Original language description

Celiac disease (CD) is a disorder that affects both children and adults. Over the few last decades, several new atypical cases have been identified through improved diagnostic tools. On the other hand, the onset of CD at a later age, including atypical CD forms whose clinical picture overlaps with other autoimmune diseases, shows that currently there are several unknown gene mutations, which could be responsible for the disease development. Non-celiac gluten sensitivity (NCGS) is entity included by the ingestion of gluten leading to intestinal, or extraintestinal symptoms that improve once the gluten is removed from the nutrition. In this article relationships between genetically modified rodent animals with previously unknown multiple organ changes and CD, respectively NCGS are reviewed. Relationships between the small bowel histological changes and other organs pathology are discussed. Results of research document that changes have similar genetic background and can develop to serious autoimmune systematic diseases, including small bowel inflammation resembling atypical CD or NCGS. These may have extra-intestinal symptomatology but without a clear explanation of causes and differences in their manifestations. Research on animal models helps to discover links between several disorders associated with gastrointestinal damage. New methods based on individual gene mutations can help in atypical adult CD and NCGS recognitions in the future.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30218 - General and internal medicine

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Central European Journal of Public Health

ISSN

1210-7778

e-ISSN

1803-1048

Volume of the periodical

30

Issue of the periodical within the volume

Supplement

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

"S27"-"S31"

UT code for WoS article

000951157900006

EID of the result in the Scopus database

2-s2.0-85134623279