Epigenetic factors in breast cancer therapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F22%3A43922022" target="_blank" >RIV/62156489:43210/22:43922022 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16170/22:43880476

Result on the web

<a href="https://doi.org/10.3389/fgene.2022.886487" target="_blank" >https://doi.org/10.3389/fgene.2022.886487</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fgene.2022.886487" target="_blank" >10.3389/fgene.2022.886487</a>

Result language

angličtina

Original language name

Epigenetic factors in breast cancer therapy

Original language description

Epigenetic modifications are inherited differences in cellular phenotypes, such as cell gene expression alterations, that occur during somatic cell divisions (also, in rare circumstances, in germ line transmission), but no alterations to the DNA sequence are involved. Histone alterations, polycomb/trithorax associated proteins, short non-coding or short RNAs, long non-coding RNAs (lncRNAs), &amp; DNA methylation are just a few biological processes involved in epigenetic events. These various modifications are intricately linked. The transcriptional potential of genes is closely conditioned by epigenetic control, which is crucial in normal growth and development. Epigenetic mechanisms transmit genomic adaptation to an environment, resulting in a specific phenotype. The purpose of this systematic review is to glance at the roles of Estrogen signalling, polycomb/trithorax associated proteins, DNA methylation in breast cancer progression, as well as epigenetic mechanisms in breast cancer therapy, with an emphasis on functionality, regulatory factors, therapeutic value, and future challenges.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10603 - Genetics and heredity (medical genetics to be 3)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Genetics

ISSN

1664-8021

e-ISSN

1664-8021

Volume of the periodical

13

Issue of the periodical within the volume

23 September

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

886487

UT code for WoS article

000875355700001

EID of the result in the Scopus database

2-s2.0-85140097436