Orally Administrable H2S-Scavenging Metal-Organic Framework Prepared by Co-Flow Microfluidics for Comprehensive Restoration of Intestinal Milieu

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F23%3A43922910" target="_blank" >RIV/62156489:43210/23:43922910 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1002/adma.202210047" target="_blank" >https://doi.org/10.1002/adma.202210047</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/adma.202210047" target="_blank" >10.1002/adma.202210047</a>

Result language

angličtina

Original language name

Orally Administrable H2S-Scavenging Metal-Organic Framework Prepared by Co-Flow Microfluidics for Comprehensive Restoration of Intestinal Milieu

Original language description

Intestinal milieu disorders are strongly related to the occurrence of inflammatory bowel diseases (IBDs), which results from mucosa destruction, epithelium disruption and tight junction (TJ) proteins loss. Excess of H2S in the intestinal milieu produced by sulfate-reducing bacteria metabolism contributes to IBDs development via epithelial barrier breakdown. Conventional interventions, such as surgery and anti-inflammatory medications, are considered not completely effective because of frequent recurrence and other complications. Herein, a novel oral delivery system, a hydroxypropyl methylcellulose acetate succinate (HPMCAS)-based polymer-coated Zr-based metal-organic framework (UiO-66) with a Cux-rhodamine B (CR) probe (hereinafter referred to as HUR), was produced via co-flow microfluidic assistance with ability to reduce H2S levels, thus restoring the intestinal lumen milieu. HPMCAS serves as an enteric coating that exposes UiO-66@CR at the pH of the intestine but not the acidic pH of the stomach. The synthesized HUR exhibits notable therapeutic efficacy, including mucosa recovery, epithelium integrity restoration and TJ proteins up-regulation via H2S scavenging to protect against intestinal barrier damage and microbiome dysbiosis. Thus, HUR has been verified to be a promising theranostic platform able to decrease the H2S content for intestinal milieu disorder treatment. The presented study therefore opens the door for further exploitation for IBDs therapy.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

21001 - Nano-materials (production and properties)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Advanced Materials

ISSN

0935-9648

e-ISSN

1521-4095

Volume of the periodical

35

Issue of the periodical within the volume

14

Country of publishing house

DE - GERMANY

Number of pages

16

Pages from-to

2210047

UT code for WoS article

000934601800001

EID of the result in the Scopus database

2-s2.0-85148460346