Magnetocaloric-Responsive Hydrogel Nanoarchitectonics for Pyroptosis-Relay-Immunotherapy to Suppress Post-Operation Tumor Recurrence and Metastasis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F24%3A43924770" target="_blank" >RIV/62156489:43210/24:43924770 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1002/adfm.202314194" target="_blank" >https://doi.org/10.1002/adfm.202314194</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adfm.202314194" target="_blank" >10.1002/adfm.202314194</a>
Alternative languages
Result language
angličtina
Original language name
Magnetocaloric-Responsive Hydrogel Nanoarchitectonics for Pyroptosis-Relay-Immunotherapy to Suppress Post-Operation Tumor Recurrence and Metastasis
Original language description
Although a widely used option in contemporary anticancer treatment, surgery still causes serious issues, including post-operation recurrence and the development of metastases. Immunotherapy, often following surgical resection of a tumor, has demonstrated benefits in improving the therapeutical outcomes of surgery. However, antigen generation and presentation play an essential role in reversing limited T-cell responses or immunological resistance. Thus, a gelatin-tannic acid gel (GelTA) crosslinked bimetallic (Zn0.35Fe0.65) magnetocaloric-responsive hydrogels (GelTAMNPs) are developed to mediate pyroptosis-relay-immunotherapy for suppressing post-operation tumor recurrence and metastasis. After surgical resection of tumor, GelTAMNPs generate hyperthermia inducible by alternating magnetic field and release ions (Fe3+, Fe2+, and Zn2+), reinforcing pyroptosis. Subsequently, the cell contents and cytokines released due to pyroptosis act as a "relay baton" passed from the tumor to the lymph nodes, leading to an enhanced systemic immune response. Combined with the PD-1 immune checkpoint blockade, the recurrence and metastasis are significantly suppressed. An in vivo preclinical study on B16F10 tumor-bearing mice demonstrates a long-lasting immunological activation due to post-surgical administration of GelTAMNPs. Altogether, the presented hydrogel exhibits a potential high magnetic sensitive pyroptosis-relay-immunotherapeutic platform for postoperative adjuvant treatment.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/GM23-04740M" target="_blank" >GM23-04740M: Hybrid biocompatible nanocatalysts for extracellular bioorthogonal activation of prodrugs</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Functional Materials
ISSN
1616-301X
e-ISSN
1616-3028
Volume of the periodical
34
Issue of the periodical within the volume
22
Country of publishing house
DE - GERMANY
Number of pages
17
Pages from-to
2314194
UT code for WoS article
001157846900001
EID of the result in the Scopus database
2-s2.0-85184189868