Garcinol in gastrointestinal cancer prevention: recent advances and future prospects

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F24%3A43925505" target="_blank" >RIV/62156489:43210/24:43925505 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1007/s00432-024-05880-6" target="_blank" >https://doi.org/10.1007/s00432-024-05880-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00432-024-05880-6" target="_blank" >10.1007/s00432-024-05880-6</a>

Result language

angličtina

Original language name

Garcinol in gastrointestinal cancer prevention: recent advances and future prospects

Original language description

Gastrointestinal cancers continue to pose a significant global health challenge, with millions of new cases diagnosed each year. Despite advancements in treatment, the prognosis for many patients remains poor. This article explores the potential of garcinol, a polyisoprenylated benzophenone found in various Garcinia species, as a therapeutic agent against gastrointestinal malignancies. The objective is to review recent research on garcinol&apos;s anticancer properties, its mechanisms of action, and safety aspects. Garcinol exhibits anticancer effects in esophageal, gastric, colorectal, pancreatic, and liver cancers by inhibiting metastasis, inducing apoptosis, and targeting key molecular pathways in cancer progression. Nanotechnology is explored as a means to enhance garcinol delivery and efficacy. Safety assessments suggest a promising toxicity profile. Garcinol shows significant potential as a natural therapeutic agent for gastrointestinal cancers, and future research is needed on optimizing its delivery, exploring synergistic combinations, and conducting clinical trials to validate its efficacy and safety for clinical applications.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30402 - Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Cancer Research and Clinical Oncology

ISSN

0171-5216

e-ISSN

1432-1335

Volume of the periodical

150

Issue of the periodical within the volume

7

Country of publishing house

DE - GERMANY

Number of pages

11

Pages from-to

370

UT code for WoS article

001281175200004

EID of the result in the Scopus database

2-s2.0-85199882784