Dual Infection of an Open Fracture Caused by Mycobacterium setense and Clostridium celerecrescens

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43310%2F22%3A43921995" target="_blank" >RIV/62156489:43310/22:43921995 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/22:10449439 RIV/00179906:_____/22:10449439

Result on the web

<a href="https://doi.org/10.3390/antibiotics11091254" target="_blank" >https://doi.org/10.3390/antibiotics11091254</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/antibiotics11091254" target="_blank" >10.3390/antibiotics11091254</a>

Result language

angličtina

Original language name

Dual Infection of an Open Fracture Caused by Mycobacterium setense and Clostridium celerecrescens

Original language description

Infections caused by Mycobacterium setense or Clostridium celerecrescens are extremely rare. In this report, for the first time a dual infection with these two pathogens is described. An 18-year-old female suffered multiple injuries, including an open comminuted fracture of the right humeral diaphysis after falling from a fifth-floor balcony in January 2019. Five months after the accident, a fistula appeared in the scar, reaching the bone tissue. M. setense and C. celerecrescens were cultured from sinus swabs and subsequently from perioperative samples. The patient was initially treated with a combination of intravenous antibiotics (ATBs): imipenem, amikacin, and ciprofloxacin. One month after the fracture fixation with a titanium nail, C. celerecrescens was again detected; therefore, metronidazole was added to the therapy. A triple combination of oral (PO) ATBs (trimethoprim-sulfamethoxazole, moxifloxacin, and metronidazole) followed, 8 weeks after the initial intravenous therapy. C. celerecrescens was cultured again two times, most recently in November 2019, when surgical debridement was supplemented by the topical administration of cancellous bone impregnated with vancomycin. Signs of bone healing were found at follow-ups and ATB treatment was finished in March 2020 after a total of 9 months of therapy. To this day, there have been no signs of reinfection. This case thus illustrates the need for a combination of systemic and individualized local therapy in the treatment of complicated cases of dual infections with rare pathogens.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30212 - Surgery

Project

<a href="/en/project/NU20-09-00114" target="_blank" >NU20-09-00114: Non-tuberculous mycobacteria in the Czech Republic: current risks and improved prevention</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Antibiotics

ISSN

2079-6382

e-ISSN

2079-6382

Volume of the periodical

11

Issue of the periodical within the volume

9

Country of publishing house

CH - SWITZERLAND

Number of pages

8

Pages from-to

1254

UT code for WoS article

000857441200001

EID of the result in the Scopus database

2-s2.0-85138552304