Plant microRNAs: An overview

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43410%2F25%3A43926674" target="_blank" >RIV/62156489:43410/25:43926674 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/B978-0-443-21682-4.00007-5" target="_blank" >https://doi.org/10.1016/B978-0-443-21682-4.00007-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-443-21682-4.00007-5" target="_blank" >10.1016/B978-0-443-21682-4.00007-5</a>

Result language

angličtina

Original language name

Plant microRNAs: An overview

Original language description

MicroRNAs (miRNAs) are endogenous, noncoding RNAs characterized by short sequences ranging from 20 to 35 nucleotides. They act as sequence-specific riboregulators prevalent in eukaryotes and prokaryotes, spanning across plants, animals, fungi, and in prokaryotes such as bacteria (pneumonia) and viruses. The history of microRNAs traces back to the late 20th century, when researchers initiated the exploration of small RNA molecules. MiRNAs impact more than 60% of genes in both animals, plants and play regulatory roles in gene expression by facilitating post-transcriptional gene silencing (PTGS) of target mRNAs at both transcriptional and post-transcriptional levels. MiRNAs influence all the essential cellular processes such as differentiation, development, gene silencing, and stress responses. The biogenesis of miRNAs involves smiRNA genes, primarily transcribed by DNA-dependent RNA polymerase II. Some miRNAs originate from RNA polymerase III cotranscripts with adjacent repetitive elements, regulated at various levels, including transcription and processing. The transformation of primary miRNA (pri-miRNA) into mature miRNA is orchestrated by the RNase III enzyme DICER-LIKE protein 1. The functional mechanism involves the formation of the miRNA-induced silencing complex (miRISC), where miRNAs guide the effector protein ARGONAUTE (AGO) to target complementary RNA sequences, leading to cleavage or translational inhibition. The negative gene expression regulation by miRISC plays a crucial role in coordinating mechanisms related to plant development, plant-environment interactions, and miRNA-based therapies for various diseases. Despite extensive knowledge available in databases, ongoing advanced research aims to comprehensively understand miRNA biogenesis, homeostasis, degradation, and their interaction with transcription and RNA metabolism. This chapter provides a thorough overview of miRNA biogenesis processes and regulations, homeostasis, degradation, and the formation of miRISC. Furthermore, it explores the regulatory roles of miRISC in plant development, signal transduction, cell differentiation, proliferation, apoptosis (programmed cell death), and immune responses against environmental stress, with a focus on recent findings related to plant miRNAs and future possibilities in this domain.

Czech name

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Czech description

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Type

C - Chapter in a specialist book

CEP classification

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OECD FORD branch

10611 - Plant sciences, botany

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name

MicroRNA Advances and Application in Plant Biology

ISBN

978-0-443-21682-4

Number of pages of the result

33

Pages from-to

1-33

Number of pages of the book

420

Publisher name

Elsevier Science Inc.

Place of publication

New York

UT code for WoS chapter

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