Harnessing Coumarins for Alzheimer’s Disease: From Molecular Targets to Clinical Prospects

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43410%2F25%3A43928152" target="_blank" >RIV/62156489:43410/25:43928152 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Harnessing Coumarins for Alzheimer’s Disease: From Molecular Targets to Clinical Prospects

Original language description

Neurodegenerative diseases, which encompass a broad spectrum of debilitating conditions, are among the most incapacitating ailments affecting humans. These diseases are characterized by the progressive degeneration of neurons in the brain, leading to impairments in cognition and mobility. Alzheimer&apos;s disease (AD) is one of the most prevalent neurodegenerative disorders, with over 30 million confirmed cases worldwide. The initial symptom of AD is often repeated episodes of short-term memory impairment, which gradually worsens and impacts more complex mental capabilities, including speech and reasoning abilities. Coumarin derivatives have emerged as promising candidates for AD treatment due to their diverse chemical structures and wide range of pharmacological properties. In addition to their acetylcholinesterase inhibition activity, these compounds exhibit several other biological effects that are beneficial in addressing various aspects of AD pathology. For instance, coumarin derivatives can inhibit secretase-1, a key enzyme involved in the production of amyloid beta plaques, a hallmark of AD. Additionally, they can act as monoamine oxidase inhibitors, modulate gamma-aminobutyric acid (GABA) receptors, and inhibit cyclooxygenase and lipoxygenase enzymes, which are involved in inflammation and oxidative stress. Furthermore, coumarin derivatives also act as blockers of cannabinoid receptor 2 and antagonists of the NMDA receptor, which play roles in synaptic dysfunction and neurodegeneration. Given these multifaceted biological effects, coumarin-based compounds show significant potential for the treatment of AD. This chapter delves into the therapeutic significance of coumarin derivatives in AD, exploring their mechanisms of action and their potential to address the underlying causes of the disease, such as neuroinflammation, oxidative stress, and amyloid plaque formation.

Czech name

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Czech description

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Type

C - Chapter in a specialist book

CEP classification

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OECD FORD branch

30308 - Nutrition, Dietetics

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name

Natural Remedies: Unveiling Phytoconstituents in Alzheimer’s Prevention and Treatment

ISBN

979-8-89530-751-9

Number of pages of the result

18

Pages from-to

271-288

Number of pages of the book

409

Publisher name

Nova Science Publishers Inc.

Place of publication

Hauppauge

UT code for WoS chapter

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