Copper(II) complexes of Schiff bases derived from beta-amino acids and their biological activity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F01%3A00000711" target="_blank" >RIV/62157124:16170/01:00000711 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16370/01:00000711

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Copper(II) complexes of Schiff bases derived from beta-amino acids and their biological activity

Original language description

Alloxan-induced diabetes was used as a model of free radical pathology to test antiradical activity of aqua-bis(-salicylidene-beta-alaninato)dicopper(II) monohydrate and N-salicylidenetaurinatocopper(II) monohydrate in vivo. Intravenous administration ofalloxan resulted in expressive in the mice hyperglycaemia. Pretreatment of animals with tested compounds in dose 0,04 mmol/kg significantly reduced the elevated blood glucose levels to normal ones. The antidiabetic action of copper complexes is more effective than conventionally used hydroxyl radical scavenger TROLOX.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Challenges for Coordination Chemistry in the New Century

ISSN

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e-ISSN

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Volume of the periodical

Neuveden

Issue of the periodical within the volume

5

Country of publishing house

SK - SLOVAKIA

Number of pages

6

Pages from-to

257-262

UT code for WoS article

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EID of the result in the Scopus database

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