Ontogenetic development of innate immunity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F06%3A00000495" target="_blank" >RIV/62157124:16170/06:00000495 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16170/06:00000595
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Ontogenetic development of innate immunity
Original language description
Pig. Developmental immunology employs the pig model because of character of epitheliochorial placentation impermeable for mother immunoglobulins. Thus studies of spontaneous development of effector defence mechanisms have excellent advantage. We focusedon innate immune responses mediated by natural killer (NK) cells, when former data were without evidence of NK cytotoxicity with conventional target cells. We used for fetal NK cytotoxicity experiments special targets - combination of xeno - and isogeneous surface determinants, i.e. rat C6 glioma cells (t -C6 cells) transfected with pig T lymphocyte determinants. Our measurements starting pig fetal day 100 up to postnatal day 35 proved NK activity with t - C6 cells significantly higher in comparison with conventional targets cells (K 562). Development of innate immune responses with NK cells is supported by high increase of bactericidal activity of piglet phagocytes against S. typhimurium, LT2 type. Goat. Goat as a ruminant model, was c
Czech name
Ontogenetický vývoj přirozené imunity
Czech description
Cílem práce bylo sledování vývoje přirozené imunity u selat a kůzlat. Pozornost byla zaměřena na imunitní reakce, zprostředkované především NK buňkami. Údaje popisující tuto oblast přirozené imunity jsou prozatím velmi omezené.
Classification
Type
M - Conference organization
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA524%2F05%2F0267" target="_blank" >GA524/05/0267: Mechanisms related to ontogenesis of immune system and their modulations</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Event location
Freiburg
Event country
FR - FRANCE
Event starting date
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Event ending date
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Total number of attendees
500
Foreign attendee count
500
Type of event by attendee nationality
WRD - Celosvětová akce