Healing of large segmental bone defekt after implantation of autogenous cancellous bone graft in comparison with hydroxyapatite and 0,5% collagen scaffold in combination with mesenchymal stem cells.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F10%3A00002578" target="_blank" >RIV/62157124:16170/10:00002578 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Healing of large segmental bone defekt after implantation of autogenous cancellous bone graft in comparison with hydroxyapatite and 0,5% collagen scaffold in combination with mesenchymal stem cells.

Original language description

At present, attention is focused on research into possibilities of healing large bone defects by the method of mini-invasive osteosynthesis, using implantation of biomaterials and mesenchymal stem cells (MSCs). This study evaluates the healing of segmental femoral defects in miniature pigs based on the radiological determination of the callus: cortex ratio at 16 weeks after ostectomy. The size of the formed callus was significantly larger (p < 0.05) in animals after transplantation of an autogenous cancellous bone graft (group A, callus : cortex ratio of 1.77 ? 0.33) compared to animals after transplantation of cylindrical scaffold from hydroxyapatite and 0.5% collagen (group S, callus : cortex ratio of 1.08 ? 0.13), or in animals after transplantationof this scaffold seeded with MSCs (group S + MSCs, callus: cortex ratio of 1.15 ? 0.18). No significant difference was found in the size of callus between animals of group S and animals of group S + MSCs. Unlike a scaffold in the shape o

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FO - Dermatology and venereology

OECD FORD branch

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Project

<a href="/en/project/2B06130" target="_blank" >2B06130: Synthesis of new biomaterials and preparation of stem cell derived cells, and their aplications in for the treatment of diseases affecting human tissues derived from mesoderm: cartilage, bone, ligament and meniscus.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta veterinaria Brno

ISSN

0001-7213

e-ISSN

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Volume of the periodical

79

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

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UT code for WoS article

000287418300013

EID of the result in the Scopus database

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