Evaluation of the Thertapeutic and Preventive Efficacy of 2.5 % Moxidectin/10% Imidacloprid (Advocate(R), Bayer Animal Health) in Dogs Naturally Infected or at Risk of Natural Infection by Dirofilaria repens

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F11%3A43870289" target="_blank" >RIV/62157124:16170/11:43870289 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00436-011-2404-6" target="_blank" >http://dx.doi.org/10.1007/s00436-011-2404-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00436-011-2404-6" target="_blank" >10.1007/s00436-011-2404-6</a>

Result language

angličtina

Original language name

Evaluation of the Thertapeutic and Preventive Efficacy of 2.5 % Moxidectin/10% Imidacloprid (Advocate(R), Bayer Animal Health) in Dogs Naturally Infected or at Risk of Natural Infection by Dirofilaria repens

Original language description

The objective of this GCP-compliant clinical field study was to evaluate the efficacy of the combination of moxidectin (minimum dose of 2.5 mg/kg body weight) and imidacloprid (minimum dose of 10.0 mg/kg body weight) spot-on (Advocate(R)) as a preventiveand therapeutic treatment of natural infection by Dirofilaria repens in dogs in the Czech Republic. There were two arms of the study, both negatively controlled. 34 animals were randomly allocated to two groups of the treatment arm; 90 negative animalswere randomly allocated to the preventiv arm groups. All enrolled dogs were observed physically and blood was sampled monthly for Dirofilaria repens microfilaria counts for 18 months by modified Knott test and PCR. 34 dogs were enrolled in the treatmentarm of this study (treated: 18, untreated: 16). The reduction of the log-transformed microfilaria counts was significantly higher in the treatment group on day 28 (p = 0.007), 56, 84 and 112 (p { 0.001). All animals treated were negative

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GJ - Diseases and animal vermin, veterinary medicine

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Parasitology Research

ISSN

0932-0113

e-ISSN

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Volume of the periodical

109

Issue of the periodical within the volume

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Country of publishing house

DE - GERMANY

Number of pages

10

Pages from-to

"S77"-86

UT code for WoS article

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EID of the result in the Scopus database

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