Diagnostic value of HMGB1 for detection of gastric necrosis in dogs with gastric dilatation-volvulus syndrome.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F13%3A43872490" target="_blank" >RIV/62157124:16170/13:43872490 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Diagnostic value of HMGB1 for detection of gastric necrosis in dogs with gastric dilatation-volvulus syndrome.
Original language description
Background: High mobility group box 1 (HMGB1) is a nuclear protein which is released from cells during cell necrosis or actively as a late cytokine. Gastric necrosis is one of the major complication and negative prognostic factor in dogs with gastric dilatation-volvulus syndrome (GDV). Objective: The aim of this study was to determinate diagnostic value of HMGB1 for detection of gastric necrosis in dogs with GDV. Methods: Fifty-four dogs with GDV were enrolled in this prospective study. Blood was collected before surgery from jugular vein and HMGB1 was detected using ELISA method (HMGB1, IBL International GmbH, Germany) from serum. Results: Sixteen dogs had macroscopically evident gastric necrosis and underwent partial gastrectomy or euthanasia. Thirty-eight dogs did not have gastric necrosis and were discharged from the hospital after successful treatment. Dogs with gastric necrosis had significantly higher HMGB1 levels (median 9.4 ng/ml, min-max 1.1-36.1 ng/ml) in comparison to those
Czech name
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Czech description
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Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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