Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F14%3A43872753" target="_blank" >RIV/62157124:16170/14:43872753 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16370/14:43872753
Result on the web
<a href="http://dx.doi.org/10.3109/14756366.2013.848204" target="_blank" >http://dx.doi.org/10.3109/14756366.2013.848204</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/14756366.2013.848204" target="_blank" >10.3109/14756366.2013.848204</a>
Alternative languages
Result language
angličtina
Original language name
Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth
Original language description
Plectranthus madagascariensis is used as a traditional medicine in Southern Africa. In search of compounds and activities supporting the medicinal use, the chemical profile of the methanolic extract was studied by high-performance liquid chromatography with diode array detection (HPLC-DAD). Four major constituents were isolated and identified as rosmarinic acid (1), 7b,6b-dihydroxyroyleanone (2), 7b-acetoxy-6b-hydroxyroyleanone (3) and coleon U quinone (4). The two abietane diterpenoids (2 and 3) were isolated for the first time from this species. Antimicrobial, cholinesterase and a-glucosidase inhibitory activities of these compounds were studied. The compounds exhibited inhibitory activity on alfa-glucosidase with IC50 values from 33 to 275 mikroM. Abietanes showed potent antibacterial activity against Staphylococcus aureus and Enterococcus faecalis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Enzyme Inhibition and Medicinal Chemistry
ISSN
1475-6366
e-ISSN
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Volume of the periodical
29
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
749-752
UT code for WoS article
000342056900020
EID of the result in the Scopus database
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