Diet-microbe co-metabolic interactions in wild primates reveal clues on human evolution

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F15%3A43873369" target="_blank" >RIV/62157124:16170/15:43873369 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Diet-microbe co-metabolic interactions in wild primates reveal clues on human evolution
Original language description
Recent advances in microbiome studies and meta-"OMICS" have offered new molecular insights into how host-microbe systems impact mammalian physiology. Here, we test the hypothesis that the molecular characterization of diet - gut microbe interactions in wild primates also provides valuable information on the factors that triggered human evolution. Thus, we use a longitudinal approach, along with high throughput sequencing and metabolomics to characterize the gut microbiome and metabolomes in 356 fecal samples of Cercocebus agilis, Gorilla beringei, Gorilla gorilla, Pan troglodites schweinfurthii and Homo sapiens. Our results show that the diet-microbe co-metabolic landscape of wild primates converges with that of humans when foraging is focused on increased energy harvest; specifically, as far as predominance of microbes and metabolites involved in simple sugar processing and lipid turnover. As such, we present evidence that primitive dietary shifts to foods with high contents of readil
Czech name
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Czech description
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Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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