Azoospermia with variable testicular histology after 7 months of treatment with a deslorelin implant in toms

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F15%3A43873432" target="_blank" >RIV/62157124:16170/15:43873432 - isvavai.cz</a>

Alternative codes found

RIV/00027162:_____/15:#0001250

Result on the web

<a href="http://dx.doi.org/10.1016/j.theriogenology.2014.12.026" target="_blank" >http://dx.doi.org/10.1016/j.theriogenology.2014.12.026</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.theriogenology.2014.12.026" target="_blank" >10.1016/j.theriogenology.2014.12.026</a>

Result language

angličtina

Original language name

Azoospermia with variable testicular histology after 7 months of treatment with a deslorelin implant in toms

Original language description

The main aim of the study was to assess whether the longer use of a GnRH-agonist implant (deslorelin 4.7 mg, Suprelorin) in toms would lead to the suppression of spermatogenesis comparable with histologic appearance in juvenile animals as was previously described in dogs. The other aims were to monitor the progression of the testes size decrease and development of azoospermia 5 to 7 months after treatment with a GnRH-agonist implant. In animals, 5, 6, and 7 months after GnRH-agonist implant insertion, variable histological appearance of germinal epithelium was found, when tubules with elongating spermatids, round spermatids, spermatocytes, and spermatogonia as the most developed germinal cells were found in each group of toms. In all male cats, 5, 6, and 7 months after implant insertion, testosterone concentrations and testes size significantly differed between the first and the last visit. All animals, except one tom castrated 5 months after implant insertion, developed complete azoospermia. However, in this tom, all spermatozoa were immotile. Treatment with the subcutaneous GnRH-agonist implant was well tolerated, and no treatment-related adverse effects were noted. These results reported the efficacy of 4.7-mg deslorelin implant (Suprelorin) during its 7 months of use. The complete azoospermia confirms its contraceptive effect. However, the histologic evaluation revealed a great individual variability in the degree of spermatogenic suppression. The question as to whether spermatogenesis in toms can be suppressed in all males to the level of spermatogonia/primary spermatocytes after prolonged exposure to deslorelin has yet to be answered.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2015

Confidentiality

U - Předmět řešení projektu je utajovanou skutečností podle zvláštních právních předpisů nebo je skutečností, jejíž zveřejnění by mohlo ohrozit činnost zpravodajské služby. Údaje o projektu jsou upraveny tak, aby byly zveřejnitelné

Name of the periodical

Theriogenology

ISSN

0093-691X

e-ISSN

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Volume of the periodical

83

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

1188-1193

UT code for WoS article

000352170900011

EID of the result in the Scopus database

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