In-Depth Characterization of Live Vaccines Used in Europe for Oral Rabies Vaccination of Wildlife
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F15%3A43873542" target="_blank" >RIV/62157124:16170/15:43873542 - isvavai.cz</a>
Alternative codes found
RIV/00027162:_____/15:#0001306
Result on the web
<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625003/" target="_blank" >http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625003/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0141537" target="_blank" >10.1371/journal.pone.0141537</a>
Alternative languages
Result language
angličtina
Original language name
In-Depth Characterization of Live Vaccines Used in Europe for Oral Rabies Vaccination of Wildlife
Original language description
Although rabies incidence has fallen sharply over the past decades in Europe, the disease is still present in Eastern Europe. Oral rabies immunization of wild animal rabies has been shown to be the most effective method for the control and elimination ofrabies. All rabies vaccines used in Europe are modified live virus vaccines based on the Street Alabama Dufferin (SAD) strain isolated from a naturally-infected dog in 1935. Because of the potential safety risk of a live virus which could revert to virulence, the genetic composition of three commercial attenuated live rabies vaccines was investigated in two independent laboratories using next genome sequencing. This study is the first one reporting on the diversity of variants in oral rabies vaccines as well as the presence of a mix of at least two different variants in all tested batches. The results demonstrate the need for vaccine producers to use new robust methodologies in the context of their routine vaccine quality controls prio
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED0006%2F01%2F01" target="_blank" >ED0006/01/01: Center for Advanced Microbiology & Immunology Research in Veterinary Medicine</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
"Nestránkováno"
UT code for WoS article
000363918100100
EID of the result in the Scopus database
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